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Disintegration of microbial cells is a necessary first step for the production of ... increasing use of intracellular microbial material in industry and medicine, the cell disruption ... 1, A constant A constant Mean residence time in the mill 1 - Symp - 1972 ... of various yeasts and bacteria in an industrial bead mill (Netzsch LME 20).
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Unit operations for microbial cell disruption are broadly classified into mechanical and nonmechanical techniques, as illustrated in Figure 3.The mechanical operations of bead milling and high-pressure homogenization (HPH) are most commonly used on the large scale [2, 6, 12], owing to their rapid handling of cell suspensions, generic application across cell types, and ease of scalability.
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